I shoot 225 gr LeveEevolution in my rifle and 210gr Win ballistic silver tips in my pistol and have killed deer with both. One doe at 108yds w rifle hit up under spine and dropped her on the spot, but most deer run about like they do with a ML. 40-80 yes w decent blood trails so far in my experience. Most factory loads are geared up for pistols and are limited to 100 yards give or take. You can hand load some geared for longer bbl slower burn powders and extend the range some, but if yourooking for long distance shooting a ML tweAked for it is a better choice.